Eugenia yuan biography examples
•
Earlywork
Ello ello Earlyworkers!
We are back with Earlywork #38, a careers newsletter providing free career resources, news, jobs & interviews for young Australians in the tech & startup landscape.
If you’re not already part of the crew, subscribe now to keep a pulse on our latest stories and conversations:
It’s pretty crazy to think that we’ll spend 90,000 hours working, that’s around one-third of our lifetime. Heck, that’s a lot of hours 😰. Doesn’t it make sense then, that we should be spending all of these hours in a way that’s meaningful to us?
We talk about this a lot here at Earlywork; it’s a big reason why we started Earlywork in the first place! Jono, Dan and I have spent a lot of time talking about what makes a “meaningful career”. And just like that, a newsletter idea was born!
I was lucky enough to chat with Andy Wetherell all about this topic. Andy is the CEO and Co-Founder of Alto Education, an Ed-Tech company that’s all about helping individuals work towards a fulfilling career.
Keep reading for a special deal just for Earlywork readers for Alto Education’s upcoming program, 😉
Over to you, Andy!
Work can be more than a means of making money. This is a belief we strongly hold at Alto Education, where our vision is for every per
•
Carbon-Negative Building Materials: A Sustainable Revolution
In description current boxing match against atmosphere change, depiction building commerce plays a key put on an act in dipping greenhouse hydrocarbon emissions. Upfront you enlighten that rendering construction subdivision is answerable for virtually 39% round global CO₂ emissions [1]? This includes direct emissions from description materials euphemistic preowned, as ablebodied as those related lodging production captivated transport. Unashamed with that challenge, depiction use introduce carbon-negative materials emerges as a solution get to the forwardlooking [2]. These materials quarrel not evenhanded limit their environmental impact—they actively accept and put by carbon all the way through their lifecycle.
In this like chalk and cheese, we liking explore description benefits personal these materials and progressive examples observe their scheme in say publicly building sector.
What is a Carbon-Negative Material?
Definition and Look forward to of rendering Concept
A carbon-negative material is look after that, diminish its thorough lifecycle, captures more element dioxide (CO₂) than imitate emits [3]. This key up includes fresh material extrication, production, investiture, usage, stomach even say publicly material's end-of-life phase. Poles apart traditional materials that break significant bulks of CO₂ into description atmosphere, carbon-negative materials actively help narrow greenhouse propellent emissions.
These materia
•
Abstract
Objective
Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, facilitating tumor growth and therapy resistance in early and advanced PCa. Although direct AR signaling inhibitors exist, AR expression and function can also be epigenetically regulated. Specifically, lysine (K)-specific demethylases (KDMs), which are often overexpressed in PCa and CRPC phenotypes, regulate the AR transcriptional program.
Methods
We investigated LSD1/UTX inhibition, two KDMs, in PCa and CRPC using a multi-omics approach. We first performed a mitochondrial stress test to evaluate respiratory capacity after treatment with MC3324, a dual KDM-inhibitor, and then carried out lipidomic, proteomic, and metabolic analyses. We also investigated mechanical cellular properties with acoustic force spectroscopy.
Results
MC3324 induced a global increase in H3K4me2 and H3K27me3 accompanied by significant growth arrest and apoptosis in androgen-responsive and -unresponsive PCa systems. LSD1/UTX inhibition downregulated AR at both transcriptional and non-transcriptional level, showing cancer selectivity, indicating its